In this article we study the concept of quaternionic bisectional curvature introduced by B. Chow and D. Yang for quaternion-K\"ahler manifolds. We show that non-negative quaternionic bisectional curvature is only realized for the quaternionic projective space. We also show that all symmetric quaternion-K\"ahler manifolds different from the quaternionic projective space admit quaternionic lines of negative quaternionic bisectional curvature. In particular this implies that non-negative sectional curvature does not imply non-negative quaternionic bisectional curvature. Moreover we give a new and rather short proof of a classification result by A. Gray on compact K\"ahler manifolds of non-negative sectional curvature.